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穿心蓮內(nèi)酯

分析標(biāo)準(zhǔn)品,HPLC≥98%

Andrographolide

CAS號(hào)：5508-58-7

分子式：C20H30O5

分子量：350.45

MDL：MFCD07778082

產(chǎn)品介紹

熔點(diǎn)：229-232℃

沸點(diǎn)：557.3 ℃ at 760 mmHg

比旋光度：-126 o (c=1.5,HAc)

外觀：白色方棱形或片狀結(jié)晶 （乙醇或甲醇）

溶解性：易溶于甲醇、乙醇和丙tong，微溶于氯仿、乙mi，難溶于水、石油醚和苯。

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)(29篇)

29. [IF=3.8] Peng Wang et al."Andrographolide protects against the intestinal barrier dysfunction and inflammatory response through modulating ETEC virulence factors in a mouse model of diarrhea."Journal of Functional Foods.2024 Dec;123:106568

28. [IF=3.8] Xiu-mei Luan et al."Improvement of polarity-based solvent system for countercurrent chromatography in the guidance of solvent selectivity: n-hexane/ethyl acetate/ alcohol solvents/water as an example."JOURNAL OF CHROMATOGRAPHY A.2024 Nov;1736:465389

27. [IF=5.1] Zhou Xuebin et al."Andrographolide Improves ApoE4-Mediated Blood–Brain Barrier Injury by Alleviating Inflammation."MOLECULAR NEUROBIOLOGY".2024 Mar;:1-18

26. [IF=4.6] Kuo Yu et al."Integrating Transcriptome and Chemical Analyses to Provide Insights into Biosynthesis of Terpenoids and Flavonoids in the Medicinal Industrial Crop Andrographis paniculate and Its Antiviral Medicinal Parts."MOLECULES".2024 Jan;29(4):852

25. [IF=3.1] Liling Wang et al."In vitro and in vivo study of andrographolide nanoparticles for the treatment of Mycoplasma pneumoniae pneumonia."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2024 Jan;:149540

24. [IF=3.9] Ma Jianping et al."Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway."BMC Complementary Medicine and Therapies.2023 Dec;23(1):1-16

23. [IF=5.195] Yue Ju et al."Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2023 Jul;951:175756

22. [IF=5.223] Ming Chen et al."Andrographolide protects BMSCs from dexamethasone-induced cellular dysfunction and promotes bone formation via the PI3K/AKT pathway."Journal of Functional Foods.2023 Jun;105:105576

21. [IF=1.892] R.  Luo et al."Andrographolide restored production performances and serum biochemical indexes and attenuated organs damage in Mycoplasma gallisepticum-infected broilers."BRITISH POULTRY SCIENCE

20. [IF=3.571] Hong Jiang et al."Systematic identification of chemical components in Fufang Shuanghua oral liquid and screening of potential active components against SARS-CoV-2 protease."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Jan;223:115118

19. [IF=5.215] Jingya Liao et al."Andrographolide Promotes Uptake of Glucose and GLUT4 Transport through the PKC Pathway in L6 Cells."Pharmaceuticals.2022 Nov;15(11):1346

18. [IF=5.811]

17. [IF=4.932] Ronglong Luo et al."Andrographolide attenuates Mycoplasma gallisepticum-induced inflammation and apoptosis by the JAK/PI3K/AKT signal pathway in the chicken lungs and primary alveolar type II epithelial cells."INTERNATIONAL IMMUNOPHARMACOLOGY. 2022 Aug;109

16. [IF=2.441] Loureiro Damasceno et al.Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability.European Journal Of Drug Metabolism And Pharmacokinetics.2021 Nov 23

15. [IF=1.287] Xiaofei Li et al."Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells:."J Int Med Res. 2020;48(8):

14. [IF=4.101] Yan Li et al."Protective effects of andrographolide against cerebral ischemia?reperfusion injury in mice."Int J Mol Med. 2021 Oct;48(4):1-13

13. [IF=0] Ying Liu et al."Andrographolide Induces Autophagic Cell Death and Inhibits Invasion and Metastasis of Human Osteosarcoma Cells in An Autophagy-Dependent Manner."Cell Physiol Biochem. 2017;44(4):1396-1410

12. [IF=2.311] Guo  Liu et al."Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells."Oncol Lett. 2018 Apr;15(4):5301-5305

11.  Liu, G., & Liu, G. (2018). Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells. Oncology Letters, 15, 5301-5305. https:##doi.org/10.3892/ol.2018.7941

10.  黃嘉玲,曾令杰,崔丹丹,陳遠(yuǎn)霞,張曉元,張浚凇.穿心蓮等級(jí)與葉莖比、浸出物及內(nèi)酯類(lèi)成分之間的相關(guān)性[J].中成藥,2020,42(10):2675-2679.

9.  曾吳靜, 許玲, 何秋伶,等. 穿心蓮農(nóng)藝性狀及其與二萜內(nèi)酯成分相關(guān)性研究[J]. 中國(guó)中藥雜志, 2019(15).

8.  邵艷華, 王建剛, 賴(lài)小平,等. 穿心蓮二萜內(nèi)酯類(lèi)成分的高效薄層色譜指紋圖譜研究[J]. 中藥材, 2014, 37(2):219-223.

7.  邵曉婷, 張瑜, 郭擇鄰,等. 載穿心蓮二萜內(nèi)酯有效部位的透明質(zhì)酸-苯硼酸納米粒的制備[J]. 中成藥, 2019, 041(011):2553-2560.

6.  孟慧, 許勇. 穿心蓮內(nèi)酯自乳化軟膠囊的制備和溶出度評(píng)價(jià)[J]. 藥學(xué)實(shí)踐雜志, 2010, 28(3):184-185.

5.  王靜嫻, 李文, 陳婷,等. 穿心蓮內(nèi)酯納米混懸劑的制備及評(píng)價(jià)[J]. 南京中醫(yī)藥大學(xué)學(xué)報(bào), 2017, 33(003):313-316.

4.  魏東艷, 魏冬梅, 滕利. 穿心蓮內(nèi)酯對(duì)宮頸癌U14荷瘤小鼠抗腫瘤作用的影響[J]. 中成藥, 2020, v.42(02):211-214.

3.  涂玉綺, 唐維平. 穿心蓮內(nèi)酯對(duì)人舌鱗癌Tca8113細(xì)胞增殖和凋亡的影響[J]. 重慶醫(yī)學(xué), 2014(14):67-69+72.

2.  魏東艷, 魏冬梅, 滕利. 穿心蓮內(nèi)酯對(duì)人宮頸癌SiHa細(xì)胞增殖、凋亡及細(xì)胞周期的影響[J]. 中國(guó)婦幼保健, 2019, 034(014):3341-3344.

1.  崔丹丹, 曾令杰, 黃嘉玲,等. 基于主成分聚類(lèi)和PLS回歸分析的穿心蓮質(zhì)量等級(jí)評(píng)價(jià)研究[J]. 中草藥, 2019.

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